Inhibition of Protein Synthesis in Mycobacterium smegmatis by a New Antibiotic Lividomycin

Lividomycin inhibited incorporation of acetate-114C , glutamic acid-1-14C, leucine-1-14C, and glycine1-14C into protein of Mycobacterium smegmatis (strain Jucho). Incorporation of acetate-1-14C and glycine1-14C into nucleic acids was also inhibited, but incorporation of these compounds into lipids was not inhibited in the presence of lividomycin. Incorporation of uridine-2-14C into nucleic acids was significantly inhibited, but incorporation of thymidine2-14C into the nucleic acid fraction was not inhibited